Paxil Info
Question:
Dear Barry — You are a welcome addition to this newsgroup. I appreciate your explanations of the migraine process as I am sure others on this ng do as well. Thank you for your referral to your website. By the way, what do you do for a living? Are you involved in medicine? Do you have headaches as well? Marnette
Response:
I just wanted to second John Quill Taylor and reiterate his explanation of why Paxil (and other selective serotonin reuptake inhibitors) work to reduce headache frequency and severity. By inhibiting the reuptake (re-absorption into the interior of nerve cells) of serotonin, Paxil and drugs like it make more extracellular serotonin available. This has a positive effect on mood, but it also has a side-effect that benefits migrainauts: it makes more serotonin available to modulate (reduce) pain transmissions. Serotonin levels are down during a migraine episode, so any help in keeping serotonin level up is helpful in preventing or moderating migraine headaches. The pain that serotonin normally modulates is caused by another neurotransmitter, adenosine triphosphate (ATP) and its metabolite adenosine. Adenosine causes migraine-like symptoms when infused in man proximal to the carotid arteries. Adenosine also inhibits serotonin release. Pain caused by ATP, which is called purinergic nociception, occurs when ATP binds to purinergic receptors located on sensory neurons. Sensory neurons occur in large numbers in the head, which explains the location of headache in the head. It also may explain the sensory disturbances called aura, photophobia, and the nausea that often accompany migraine. I invite everybody participating in the alt.support.headaches.migraine newsgroup to visit my website, called MigraineZine. Please read my paper about purinergic nociception as a model for migraine, at this URL: http://www.batnet.com/spencer/purine3.html -Barry Spencer
Response:
Cline) writes: My doc prescribed Paxil for me…Can anyone who takes this RX tell me a little bit about it ??????? Thanks David Cline
Hi David, Im Scott….ive been on paxil for nine months now…i had an addiction to vicodin, went into recovery, and they put me on paxil…to be honest, i dont "feel" anything..at first…i had a super libido, lately, not so super….im gonna go off of it next month…it probably did help me but i am just unaware in what way. Scott
Response:
My doc prescribed Paxil for me…Can anyone who takes this RX tell me a little bit about it ???????
here’s a real low-tech, layman’s explanation: paxil, like zoloft and effexor and possibly wellbutrin, targets specific neurotransmitters in the brain stem, and prevents their re-uptake. it is unlike prozac, in that prozac is more broad spectrum and "paints with a broader brush." i found paxil to affect (reduce) the sex drive just like the other drugs listed above. or, more technically, read: http://www.fairlite.com/ocd/medications/paxil.shtml which begins: "Paxil (paroxetine hydrochloride) is an orally administered antidepressant with a chemical structure unrelated to other selective serotonin reuptake inhibitors (SSRI) or to tricyclic, tetracyclic or other available antidepressant agents. It is the hydrochloride salt of a phenylpiperidine compound identified chemically as (-)-trans-4R-(4′-fluorophenyl)-3S [93', 4'-methylenedioxyphenoxy) methyl] piperidine hydrochloride hemihydrate and has the empirical formula of C19 H20 FNO3.HCL.1/2 H2 O. The molecular weight is 374.8 (329.4 as free base)…"
Response:
: My doc prescribed Paxil for me…Can anyone who takes : this RX tell me a little bit about it ??????? What did your doctor say? Try one of the web searchers for further info. There’s a lot out there. Priscilla
Response:
My doc prescribed Paxil for me…Can anyone who takes this RX tell me a little bit about it ??????? Thanks David Cline
